Tert-Butylamine → N-tert-butyl-4-fluorobenzenesulfonamide

HRID 1796293ノート

反応式

HRID 1796293 の反応式
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>C(Cl)Cl>[C:1]([NH:5][S:20]([C:17]1[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=1)(=[O:22])=[O:21])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 6385Tert-ButylamineHCID 8471TriethylamineHCID 95884-Fluorobenzenesulfonyl chloride

生成物 1

HCID 669058N-tert-butyl-4-fluorobenzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Into a DCM solution (50 mL) of tert-butylamine (5.9 mL, 56.5 mmol) and triethylamine (7.16 mL, 51.3 mmol) at 0° C. was slowly added a DCM solution (20 mL) of 4-fluoro-benzenesulfonyl chloride (10 g, 51.3 mmol), and the reaction stirred at RT for 19 h. The reaction was concentrated and the resulting solid recrystalized from ether/hexanes to get the product (9.5 g, 80% )as white crystals. MS: APCI (AP+): 230.1 (M)+.

後処理

  1. concentrationThe reaction was concentrated
  2. customthe resulting solid recrystalized from ether/hexanes
  3. customto get the product (9.5 g, 80%

出典と根拠

ORDレコード
ord-aaba51344f3548f3a61e57a05f4377ff
出典データセット
uspto-grants-2006_04
特許番号
US07030141B2

反応ノート

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