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Acetic Anhydride → 1-[2-(Chloromethyl)-1h-benzimidazol-1-yl]ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 2-Chloromethylbenzimidazole | HCID 78571 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 生成物 | 1-[2-(Chloromethyl)-1h-benzimidazol-1-yl]ethanone | HCID 267404 | 57% |
反応手順
2-(Chloromethyl)-1H-benzimidazole (3.32 g, 0.02 mol) and DMAP (0.2 g) in Ac2O (50 ml) were refluxed for 8 h. The excess Ac2O was evaporated under vacuum and the residue was purified by column chromatography (silica, EtOAc:hexanes 2:1, first fraction) to obtain 2.37 g of product 7 (57%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07030150B2 |
| 出典データセット | uspto-grants-2006_04 |
| ORD ID | ord-96bd3d86a5bb4ad297ba9d20200d8e5a |
| 出典メモ | uspto-grants-2006_04 |