関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Benzeneacetic acid, 4-ethoxy- | HCID 78631 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 2-(4-ethoxyphenyl)acetyl Chloride | HCID 11629782 | 94.2% |
反応手順
To a stirred solution of (4-ethoxyphenyl)acetic acid (10.0 g, 55.5 mmol) in benzene (100 mL) was added thionyl chloride (50 mL, 68.5 mmol) and the reaction mixture was stirred at 80° C. for 2 hours. The solvent was evaporated in vacuo and the crude product was purified by distillation (bp 86° C., 0.4 Torr) to provide the title compound (10.39 g, 94%) as a yellow oil. MS of methyl ester: MS (ESI) (M+H)+=194.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07030139B2 |
|---|
| 出典データセット | uspto-grants-2006_04 |
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| ORD ID | ord-a4973ff8d05341179cbddab8e5d61986 |
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| 出典メモ | uspto-grants-2006_04 |
|---|
