Hydrazine → 1-Amino-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

HRID 1796623ノート

反応式

HRID 1796623 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]([N:18]2C(=O)C3C(=CC=CC=3)C2=O)[CH:8]=[C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:10]=1[O:11][CH3:12])=[O:5])[CH3:2].NN>CCO>[CH2:1]([O:3][C:4]([C:6]1[N:7]([NH2:18])[CH:8]=[C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:10]=1[O:11][CH3:12])=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 9321HydrazineHCID 693272701-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

生成物 1

HCID 129859111-Amino-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester収率 74.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 393D (0.58 g, 1.58 mmol) and NH2NH2 (60 μl, 2.21 mmol) in EtOH (5 ml) was stirred at rt overnight, filtered through Celite, the filtrate was concentrated and the residue was purified by silica gel flash column chromatography to give 393E (0.30 g, 75%) (0%-5% EtOAc—CH2Cl2).

後処理

  1. filtrationfiltered through Celite
  2. concentrationthe filtrate was concentrated
  3. customthe residue was purified by silica gel flash column chromatography

出典と根拠

ORDレコード
ord-4f3ffa5678524a1a8aa0ce1e435ed189
出典データセット
uspto-grants-2006_04
特許番号
US07030112B2

反応ノート

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