化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → diethyl 1H-pyrrole-2,5-dicarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | ethyl 5-formyl-1H-pyrrole-2-carboxylate | HCID 321485 | — |
| 触媒 | Manganese dioxide | HCID 14801 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | diethyl 1H-pyrrole-2,5-dicarboxylate | HCID 21025083 | 76.7% |
反応手順
To a mixture of 406A (167 mg, 1.0 mmol), KCN (325.6 mg, 5.0 mmol) in anhydrous EtOH (20 ml) was added AcOH (85.9 μl, 1.5 mmol) followed by activated MnO2 (1.643 g, 20 mmol). The reaction was stirred overnight. After workup, the residue was purified by silica gel flash column chromatography to give 406B (162 mg, 77%) as a pinkish solid (25% EtOAc—hexanes).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07030112B2 |
| 出典データセット | uspto-grants-2006_04 |
| ORD ID | ord-73c257903a4e4b13ab81a84fd824f0af |
| 出典メモ | uspto-grants-2006_04 |