3-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl bromide → 2-(Tetrahydropyran-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl]piperazin-1-yl]-3,4-dihydro-2H-isoquinolin-1-one
反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[CH:13][CH:14]=2)[C:9]1=[O:31].[F:32][C:33]([F:56])([F:55])[CH2:34][NH:35][C:36]([C:38]1([CH2:51][CH2:52][CH2:53]Br)[C:50]2[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=2[C:44]2[C:39]1=[CH:40][CH:41]=[CH:42][CH:43]=2)=[O:37]>>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][N:21]([CH2:53][CH2:52][CH2:51][C:38]4([C:36](=[O:37])[NH:35][CH2:34][C:33]([F:32])([F:55])[F:56])[C:50]5[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=5[C:44]5[C:39]4=[CH:40][CH:41]=[CH:42][CH:43]=5)[CH2:20][CH2:19]3)=[CH:13][CH:14]=2)[C:9]1=[O:31]参加物
3
反応物 2
生成物 1
実験手順
Step (b) of Example 97 was repeated, except that the compound prepared in step (a) of Example 99 and the compound prepared in step (a) of Example 93 were used as the starting compounds. Thus, the title compound was prepared.