1,2-Dichloroethane → HCID 178427617、化合物

HRID 1797009ノート

反応式

HRID 1797009 の反応式
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]([C@H:14]3[CH2:19][CH2:18][C@H:17]([C:20](O)=[O:21])[CH2:16][CH2:15]3)[NH:12][CH:13]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:25][C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH2:35])(=[O:34])=[O:33])=[CH:28][CH:27]=1.C(Cl)CCl>CN(C1C=CN=CC=1)C.ClCCl>[CH3:25][C:26]1[CH:27]=[CH:28][C:29]([S:32]([NH:35][C:20]([C@H:17]2[CH2:16][CH2:15][C@H:14]([C:11]3[NH:12][CH:13]=[C:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:24])([F:23])[F:1])[CH:4]=4)[N:10]=3)[CH2:19][CH2:18]2)=[O:21])(=[O:34])=[O:33])=[CH:30][CH:31]=1

参加物

6

反応物 3

HCID 111,2-DichloroethaneHCID 6269P-ToluenesulfonamideHCID 178525698HCID 178525698、化合物

生成物 1

HCID 178427617HCID 178427617、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

To an ice-water cooled mixture of trans-4-{4-[3-(trifluoromethyl)phenyl]imidazol-2-yl}cyclohexanecarboxylic acid (1.48 mmol), 4-methylbenzenesulfonamide (1.48 mmol), and DMAP (1.48 mmol) in dichloromethane (10 mL) under nitrogen, EDC (1.48 mmol) was added. The mixture was stirred at room temperature overnight, concentrated and chromatographed on silica gel (19:1 EtOAc-MeOH eluent) to give trans-N-[(4-methylphenyl)sulfonyl](4-{4-[3-(trifluoromethyl)phenyl]-imidazol-2-yl}cyclohexyl)carboxamide.

後処理

  1. concentrationconcentrated
  2. customchromatographed on silica gel (19:1 EtOAc-MeOH eluent)

出典と根拠

ORDレコード
ord-6dedc0391ba74b9cac004d5bf1e8141e
出典データセット
uspto-grants-2006_04
特許番号
US07034034B2

反応ノート

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