Potassium Hydroxide → 2-Bromo-6-ethyl-pyridine 1-oxide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH3:9])[N:3]=1.[OH-:10].[K+]>C(O)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH3:9])[N+:3]=1[O-:10]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 2-bromo-6-ethyl-pyridine (15.4 g, 82.8 mmol) (S. G. Davies and M. R. Shipton, J. Chem. Soc., Perkin Trans. 1, 1991, 3, 501) in acetic acid (15 ml) peracetic acid (26 ml of a 39% solution) was added maintaining T<50° C. After completed addition the mixture was stirred at 50° C. for 5 hr and then cooled to rt. Crushed ice (40 g) was added and the mixture was made basic (pH 12) using 40% KOH solution. After extraction with CHCl3 (6×60 ml) the combined organic phases were dried (Na2CO3) and evaporated to give 20.0 g (>100%) of the title compound, MS: m/e=201 (M+) as a yellow oil.
後処理
- additionaddition the mixture
- temperaturecooled to rt
- extractionAfter extraction with CHCl3 (6×60 ml) the combined organic phases
- dry with materialwere dried (Na2CO3)
- customevaporated
出典と根拠
- ORDレコード
- ord-b82e9822b2884a798fc6e1064a383bdd
- 出典データセット
- uspto-grants-2006_04
- 特許番号
- US07034044B2
反応ノート
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