1-Methylhydantoin → 3-(2-{[5-Bromo-2-({3-chloro-4-[(2-methylphenyl)carbonyl]phenyl}amino)benzyl]oxy}ethyl)-1-methylimidazolidine-2,4-dione

HRID 1797332ノート

反応式

HRID 1797332 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH2:25][O:26][CH2:27][CH2:28]O)[CH:3]=1.[CH3:30][N:31]1[CH2:37][C:35](=[O:36])[NH:34][C:32]1=[O:33]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH:3]=1)[CH2:25][O:26][CH2:27][CH2:28][N:34]1[C:35](=[O:36])[CH2:37][N:31]([CH3:30])[C:32]1=[O:33]

参加物

3

反応物 2

HCID 692171-MethylhydantoinHCID 10227340[4-({4-Bromo-2-[(2-hydroxyethoxy)methyl]phenyl}amino)-2-chlorophenyl](2-methylphenyl)methanone

生成物 1

HCID 221745533-(2-{[5-Bromo-2-({3-chloro-4-[(2-methylphenyl)carbonyl]phenyl}amino)benzyl]oxy}ethyl)-1-methylimidazolidine-2,4-dione

実験手順

Compound 158 (47 mg, 0.1 mmol) and methylhydantoin (16 mg, 0.14 mmol) were treated as described in the preparation of compound 219. Purification was done by flash chromatography (petroleum ether/ethyl acetate 1:1) to provide the title compound, which was impure. The product was further purified by preparative TLC (petroleum ether/ethyl acetate 1:1) to furnish the pure title compound as yellow oil.

後処理

  1. customPurification

出典と根拠

ORDレコード
ord-b81319042a5f42fbaab028742553cb25
出典データセット
uspto-grants-2006_04
特許番号
US07034015B2

反応ノート

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