Hydrochloric Acid → HCID 22175367、化合物
反応式
[CH2:1]([O:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[N:8]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:7]1(/C=C/C(N)=O)[CH2:21][NH:22]C(OC(C)(C)C)=O)[CH2:2][CH2:3][CH3:4].[ClH:35]>C(OCC)(=O)C>[ClH:35].[NH2:22][CH2:21][C:7]1[N:8]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:9](=[O:16])[C:10]2[C:15]([C:6]=1[O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[CH:14][C:13](/[CH:11]=[CH:10]/[C:9]([NH2:8])=[O:16])=[CH:12][CH:11]=2参加物
4
実験手順
To a solution of (E)-3-(4-butoxy-3-[[(tert-butoxycarbonyl)amino]methyl]-2-isobutyl-1-oxo-1,2-dihydro-3-isoquinolinyl)-2-propenamide (0.14 g, 0.3 mmol) in ethyl acetate (5 mL) was added a solution of 4N hydrogen chloride in ethyl acetate (5 mL) and the obtained solution was stirred at room temperature for 2 h. The reaction mixture was concentrated under reduced pressure, and the precipitated crystals were recrystallized from methanol-diisopropyl ether to give (E)-3-[3-(aminomethyl)-4-butoxy-2-isobutyl-1-oxo-1,2-dihydro-6-isoquinolinyl]-2-propenamide hydrochloride (0.11 g, 91.7%) as crystals.