Imidazole → (R)-3-(tert-butyldiphenylsilyloxy)dihydrofuran-2(3H)-one

HRID 1797860

反応式

HRID 1797860 の反応式
[OH:1][C@@H:2]1[CH2:6][CH2:5][O:4][C:3]1=[O:7].N1C=CN=C1.[Si:13](Cl)([C:26]([CH3:29])([CH3:28])[CH3:27])([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(Cl)Cl>[Si:13]([O:1][C@@H:2]1[CH2:6][CH2:5][O:4][C:3]1=[O:7])([C:26]([CH3:29])([CH3:28])[CH3:27])([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 795ImidazoleHCID 94078tert-ButyldiphenylchlorosilaneHCID 71570702-Hydroxy-gamma-butyrolactone, (2R)-

生成物 1

HCID 53797635(R)-3-(tert-butyldiphenylsilyloxy)dihydrofuran-2(3H)-one収率 93%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of (R)-3-hydroxydihydrofuran-2(3H)-one (41.0 g, 401 mmol), imidazole (61.4 g, 920 mmol), and CH2Cl2 (175 mL) at 0° C., under N2, was added t-butyldiphenylsilyl chloride (129 mL, 138 g, 497 mmol) dropwise over 30 minutes. The mixture was stirred at room temperature for 19 hours. The mixture was partitioned between CH2Cl2 (700 mL) and H2O (100 mL). The organic portion was concentrated to dryness under reduced pressure. The residue was purified by silica gel chromatography (50% EtOAc in hexane) to afford (R)-3-(tert-butyldiphenylsilyloxy)dihydrofuran-2(3H)-one (127 g, 373 mmol, 93% yield) as a white solid. 1H-NMR (400 MHz, CDCl3) δ 7.84-7.82 (m, 2H), 7.73-7.71 (m, 2H), 7.50-7.40 (m, 6H), 4.41-4.31 (m, 2H), 4.06-4.00 (m, 1H), 2.29-2.19 (m, 2H), 1.10 (s, 9H).

後処理

  1. customThe mixture was partitioned between CH2Cl2 (700 mL) and H2O (100 mL)
  2. concentrationThe organic portion was concentrated to dryness under reduced pressure
  3. customThe residue was purified by silica gel chromatography (50% EtOAc in hexane)

出典と根拠

ORDレコード
ord-d67be12dce6741249fa9dc1d935edf1f
出典データセット
uspto-grants-2013_01
特許番号
US08343763B2

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