Hydrogen Peroxide → 5-Bromopyrazine-2-carboxamide

HRID 1798237ノート

反応式

HRID 1798237 の反応式
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.C(=O)([O-])[O-:11].[K+].[K+].OO.O>CS(C)=O.CC(C)=O>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([NH2:9])=[O:11])=[N:6][CH:7]=1

参加物

6

反応物 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 11430Potassium CarbonateHCID 378187222-Bromo-5-cyanopyrazine

生成物 1

HCID 582925675-Bromopyrazine-2-carboxamide収率 27.5%

試薬・触媒・溶媒 1

HCID 21922538Acetone dimethyl sulfoxide溶媒

反応条件

温度
65 °C

実験手順

A suspension of 5-bromo-pyrazine-2-carbonitrile (1.84 g, 10.0 mmol) and potassium carbonate (1.38 g, 10.0 mmol) in DMSO/acetone (16 mL, 1:3) was treated with H2O2 (2.42 mL, 25.0 mmol) at 65° C. over 15 min. The reaction was kept stirring at 65° C. 1 h. Water (2 mL) was added at 40° C. and the suspension was cooled to 0° C. The precipitate was filtered to give the title compound as a yellow solid (556 mg). 1H NMR (300 MHz, DMSO-d6) δ 9.06 (s, 1H), 8.94 (s, 1H), 8.34 (s, 1H), 7.92 (s, 1H).

後処理

  1. custom1 h
  2. temperaturethe suspension was cooled to 0° C
  3. filtrationThe precipitate was filtered

出典と根拠

ORDレコード
ord-635e9ca714c541c7abf8d297d4fcdbcb
出典データセット
uspto-grants-2013_01
特許番号
US08343944B2

反応ノート

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