Methanol → HCID 178484335、化合物

反応式

[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.CO.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>>[CH3:15][N:16](/[CH:18]=[N:8]/[C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[CH:3][CH:4]=1)[CH3:17]

参加物

反応物 3

HCID 887Methanol

HCID 650524-Hydroxybenzamide

HCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 178484335HCID 178484335、化合物

実験手順

A solution of 4-hydroxybenzamide (5.58 g, 40 mmol) in 15 mL of dimethylformamide dimethyl acetal was stirred at 120° C. for 1.5 h with distillation of the product methanol. After cooling, the solid was collected and tritrarated with diethyl ether, DCM to give desired product.