2-Chloro-4,5-dimethylpyrimidine → 2-{2-[1-(4,5-Dimethylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol
反応式
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][N:3]=1.[OH:10][CH2:11][CH2:12][C@H:13]1[CH2:15][C@H:14]1[CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1>>[CH3:8][C:6]1[C:5]([CH3:9])=[CH:4][N:3]=[C:2]([N:19]2[CH2:20][CH2:21][CH:16]([CH:14]3[CH2:15][CH:13]3[CH2:12][CH2:11][OH:10])[CH2:17][CH2:18]2)[N:7]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
The titled compound was prepared from 2-chloro-4,5-dimethylpyrimidine and rac cis-tert-Butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate by a procedure analogous to that described in Example 6, step 2, with the exception of reaction temperature and time. The reaction was heated at 90° C. for 2 h.
後処理
- customthat described in Example 6, step 2, with the exception of reaction temperature and time
出典と根拠
- ORDレコード
- ord-9ae2aa42e5cd48e8b5f1e39dadf16b13
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08343990B2
反応ノート
読み込み中…