2-Chloro-5-fluoro-4-methylpyrimidine → 2-{2-[1-(5-Fluoro-4-methylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol
反応式
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([F:9])=[CH:4][N:3]=1.C(OC([N:17]1[CH2:22][CH2:21][CH:20]([C@@H:23]2[CH2:25][C@@H:24]2[CH2:26][CH2:27][OH:28])[CH2:19][CH2:18]1)=O)(C)(C)C>>[F:9][C:5]1[C:6]([CH3:8])=[N:7][C:2]([N:17]2[CH2:22][CH2:21][CH:20]([CH:23]3[CH2:25][CH:24]3[CH2:26][CH2:27][OH:28])[CH2:19][CH2:18]2)=[N:3][CH:4]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
The titled compound was prepared from 2-chloro-5-fluoro-4-methylpyrimidine and rac cis-tert-Butyl-4-[-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate by a procedure analogous to example 6 step 2, with the exception of reaction temperature. The reaction was heated at 90° C. for 2 h.
出典と根拠
- ORDレコード
- ord-4495146233c249cabe34a17605046948
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08343990B2
反応ノート
読み込み中…