Potassium Carbonate → 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

HRID 1798948ノート

反応式

HRID 1798948 の反応式
[CH:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17]Cl)=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>CCO>[Cl:10][C:11]1[N:12]=[CH:13][C:14]([CH2:17][N:7]2[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]2)=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 780131-IsopropylpiperazineHCID 1554792-Chloro-5-(chloromethyl)pyridine

生成物 1

HCID 434217841-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
65 °C

実験手順

Isopropylpiperazine (2.3 g, 17.94 mmol), 2-chloro-5-chloromethylpyridine (3.2 g, 19.73 mmol) and K2CO3 (26.91 g, 3.713 mmol) were mixed in EtOH (50 mL) a strongly exothermic reaction. The reaction was heated further for 12 hours at 65° C. The reaction mixture was filtered and evaporated. The crude product was used without any further purification.

後処理

  1. customa strongly exothermic reaction
  2. filtrationThe reaction mixture was filtered
  3. customevaporated
  4. customThe crude product was used without any further purification

出典と根拠

ORDレコード
ord-0f22ffb33d324a43b8d7b507ff606544
出典データセット
uspto-grants-2013_01
特許番号
US08344001B2

反応ノート

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