2-Methylpyridine-4-boronic acid → 5-(4-Isopropylpiperazin-1-ylmethyl)-2'-methyl-[2,4']bipyridinyl, trihydrochloride

HRID 1798949ノート

反応式

HRID 1798949 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:18][C:19]1[CH:24]=[C:23](B(O)O)[CH:22]=[CH:21][N:20]=1>>[ClH:1].[ClH:1].[ClH:1].[CH:15]([N:12]1[CH2:13][CH2:14][N:9]([CH2:8][C:5]2[CH:4]=[CH:3][C:2]([C:23]3[CH:22]=[CH:21][N:20]=[C:19]([CH3:18])[CH:24]=3)=[N:7][CH:6]=2)[CH2:10][CH2:11]1)([CH3:17])[CH3:16]

参加物

3

反応物 2

HCID 41926642-Methylpyridine-4-boronic acidHCID 434217841-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

生成物 1

HCID 1317301375-(4-Isopropylpiperazin-1-ylmethyl)-2'-methyl-[2,4']bipyridinyl, trihydrochloride

実験手順

1-(6-Chloropyridin-3-ylmethyl)-4-isopropylpiperazine (0.2 g, 0.788 mmol) and 2-methylpyridin-4-boronic acid (0.119 g, 0.867 mmol) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as yellow crystals of the trihydrochloride. Yield: 295 mg (73%).

後処理

  1. customreacted in the same manner as in example 18

出典と根拠

ORDレコード
ord-df55b194c1214e7ca136b92876f79dd9
出典データセット
uspto-grants-2013_01
特許番号
US08344001B2

反応ノート

読み込み中…