1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine → 4-[5-(4-Isopropylpiperazin-1-ylmethyl)pyridin-2-yl]-N,N-dimethylbenzenesulfonamide, trihydrochloride
反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:18][N:19]([CH3:32])[S:20]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)(=[O:22])=[O:21]>>[ClH:1].[ClH:1].[ClH:1].[CH:15]([N:12]1[CH2:13][CH2:14][N:9]([CH2:8][C:5]2[CH:4]=[CH:3][C:2]([C:26]3[CH:25]=[CH:24][C:23]([S:20]([N:19]([CH3:32])[CH3:18])(=[O:21])=[O:22])=[CH:28][CH:27]=3)=[N:7][CH:6]=2)[CH2:10][CH2:11]1)([CH3:17])[CH3:16]参加物
3
実験手順
1-(6-Chloropyridin-3-ylmethyl)-4-isopropylpiperazine (0.5 g, 1.97 mmol) and 4-(N,N-dimethylaminosulfonyl)phenylboronic acid (0.496 g, 2.2 mmol)) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as white crystals of the trihydrochloride. Yield: 660 g (71%)
後処理
- customreacted in the same manner as in example 18
出典と根拠
- ORDレコード
- ord-3cb89b0f36104ff1830c969c608a4ac6
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08344001B2
反応ノート
読み込み中…