1,4-Dioxane hydrochloride → N,N-dimethylazetidine-3-carboxamide hydrochloride

HRID 1799027ノート

反応式

HRID 1799027 の反応式
[CH3:1][N:2]([CH3:16])[C:3]([CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:17].O1CCOCC1>>[ClH:17].[CH3:1][N:2]([CH3:16])[C:3]([CH:5]1[CH2:8][NH:7][CH2:6]1)=[O:4]

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59492610Tert-butyl 3-(dimethylcarbamoyl)azetidine-1-carboxylate

生成物 1

HCID 53308702N,N-dimethylazetidine-3-carboxamide hydrochloride

実験手順

A mixture of t-butyl 3-dimethylcarbamoyl-azetidine-1-carboxylate (0.365 g) and 4N hydrogen chloride/dioxane solution (5 ml) was stirred at room temperature for 5 hr 15 min. The reaction mixture was concentrated under reduced pressure, dioxane was added to the obtained residue and the mixture was concentrated again under reduced pressure. The obtained residue was dried under reduced pressure at 60° C. to give the title compound (0.290 g). The obtained residue was directly used for the next reaction without further purification.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure, dioxane
  2. additionwas added to the obtained residue
  3. concentrationthe mixture was concentrated again under reduced pressure
  4. customThe obtained residue was dried under reduced pressure at 60° C.

出典と根拠

ORDレコード
ord-3952b8cd197842188963e54652bc2976
出典データセット
uspto-grants-2013_01
特許番号
US08343994B2

反応ノート

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