(5-(2-(4-Chlorophenyl)-1,3-dioxolan-2-yl)-2-(methylamino)pyridin-3-yl)(3-methoxyphenyl)methanol → (5-(2-(4-Chlorophenyl)-1,3-dioxolan-2-yl)-2-(methylamino)pyridin-3-yl)(3-methoxyphenyl)methanone
反応式
C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([C:24]3[CH:25]=[C:26]([CH:32]([C:34]4[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=4)[OH:33])[C:27]([NH:30][CH3:31])=[N:28][CH:29]=3)[O:23][CH2:22][CH2:21][O:20]2)=[CH:15][CH:14]=1>C(Cl)Cl>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([C:24]3[CH:25]=[C:26]([C:32]([C:34]4[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=4)=[O:33])[C:27]([NH:30][CH3:31])=[N:28][CH:29]=3)[O:20][CH2:21][CH2:22][O:23]2)=[CH:15][CH:14]=1参加物
4
実験手順
PCC (21.19 g, 98.58 mmol) was added to a solution of compound F (28 g, 65.72 mmol) in DCM (550 mL). The mixture was stirred at RT overnight and filtered through a pad of celite. The filtrate was concentrated and purified by column chromatography to obtain 16 g (46%, 2 steps) of compound G.