4-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide → 4-(Cyclopropylmethoxy)-N-{1-[4-(difluoromethoxy)benzyl]-2-[(2-hydroxyethyl)amino]-2-oxoethyl}benzamide
反応式
C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[CH:33]1([CH2:36][O:37][C:38]2[CH:64]=[CH:63][C:41]([C:42]([NH:44]/[C:45](/[C:57]([NH:59][CH2:60][CH2:61][OH:62])=[O:58])=[CH:46]\[C:47]3[CH:52]=[CH:51][C:50]([O:53][CH:54]([F:56])[F:55])=[CH:49][CH:48]=3)=[O:43])=[CH:40][CH:39]=2)[CH2:35][CH2:34]1>>[CH:33]1([CH2:36][O:37][C:38]2[CH:64]=[CH:63][C:41]([C:42]([NH:44][CH:45]([CH2:46][C:47]3[CH:48]=[CH:49][C:50]([O:53][CH:54]([F:56])[F:55])=[CH:51][CH:52]=3)[C:57]([NH:59][CH2:60][CH2:61][OH:62])=[O:58])=[O:43])=[CH:40][CH:39]=2)[CH2:35][CH2:34]1参加物
3
反応物 2
生成物 1
実験手順
A reaction similar to that described in Example (1 (1e) was conducted using 4-(cyclopropylmethoxy)-N-((Z)-2-[4-(difluoromethoxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide (279 mg) to give 227 mg of the title compound (white powder).