4-Oxazolin-2-one → 4-(cyclopropylmethoxy)-N-((Z)-2-(4-cyclopropylphenyl)-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide
反応式
[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[CH:32]=[CH:31][C:10]([C:11]([NH:13]/[C:14](/[C:25]([NH:27][CH2:28][CH2:29][OH:30])=[O:26])=[CH:15]\[C:16]3[CH:21]=[CH:20][C:19]([CH:22]4[CH2:24][CH2:23]4)=[CH:18][CH:17]=3)=[O:12])=[CH:9][CH:8]=2)C[CH2:2]1.O1C=CNC1=O>>[CH:4]1([CH2:5][O:6][C:7]2[CH:32]=[CH:31][C:10]([C:11]([NH:13]/[C:14](/[C:25]([NH:27][CH2:28][CH2:29][OH:30])=[O:26])=[CH:15]\[C:16]3[CH:21]=[CH:20][C:19]([CH:22]4[CH2:24][CH2:23]4)=[CH:18][CH:17]=3)=[O:12])=[CH:9][CH:8]=2)[CH2:2][CH2:1]1参加物
3
実験手順
A reaction similar to that described in Example 1 (1c) was conducted using N-[4-(cyclopropylmethoxy)benzoyl]glycine (299 mg) prepared in Example 18 (18b) and 4-cyclopropylbenzaldehyde (184 mg) to give the corresponding oxazolone (366 mg). A reaction similar to that described in Example (1 (1d) was conducted using all this oxazolone to give 385 mg of 4-(cyclopropylmethoxy)-N-((Z)-2-(4-cyclopropylphenyl)-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide (white powder).
後処理
- customA reaction similar to
出典と根拠
- ORDレコード
- ord-3b0ed3eb4d644b41a6f1a6e244d9c05c
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08344029B2
反応ノート
読み込み中…