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2,2-Difluoroethanamine → N-{2-[(2,2-Difluoroethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2-Difluoroethanamine | HCID 136274 | — |
| 反応物 | 3-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid | HCID 78068623 | — |
| 生成物 | N-{2-[(2,2-Difluoroethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide | HCID 57972095 | 80.9% |
反応手順
A reaction similar to that described in Example 32 (32c) was conducted using 3-[4-(trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid (233 mg) prepared in Example 70 (70a) and 2,2-difluoroethylamine (49 mg) to give 214 mg of the title compound (white powder).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08344029B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-fd50158923be47fdb6e1e13c46603f1e |
| 出典メモ | uspto-grants-2013_01 |