Hydrochloric Acid → [2,6-Difluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

HRID 1799535ノート

反応式

HRID 1799535 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:13]([OH:16])([CH3:15])[CH3:14])[CH:5]=[C:6]([F:12])[C:7]=1[CH:8]=[CH:9][O:10]C.Cl>CC(C)=O>[F:1][C:2]1[CH:3]=[C:4]([C:13]([OH:16])([CH3:14])[CH3:15])[CH:5]=[C:6]([F:12])[C:7]=1[CH2:8][CH:9]=[O:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 670288782-{3,5-Difluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol

生成物 1

HCID 59525773[2,6-Difluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 2-{3,5-difluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol (5.0 g, 22 mmol) in acetone (25 mL) was added dropwise to 4 M aqueous hydrochloric acid (25 mL, 100 mmol) with ice-water cooling, keeping the temperature below 10° C. Then the mixture was stirred at room temperature for six hours. The resulting mixture was extracted with ethyl acetate (2×) and the combined organic phases were washed with saturated aqueous sodium bicarbonate and brine. The organic layer was then dried and concentrated in vacuo to afford the title compound.

後処理

  1. customthe temperature below 10° C
  2. extractionThe resulting mixture was extracted with ethyl acetate (2×)
  3. washthe combined organic phases were washed with saturated aqueous sodium bicarbonate and brine
  4. customThe organic layer was then dried
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2bb9eb1ddd804cc798f7e3655950dcd1
出典データセット
uspto-grants-2013_01
特許番号
US08344144B2

反応ノート

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