2-chloro-6-[(3-methyloxetan-3-yl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(3-methyloxetan-3-yl)methyl]-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 1799548

反応式

HRID 1799548 の反応式
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[C:27]2[CH2:29][N:30]([CH2:33][C:34]3([CH3:38])[CH2:37][O:36][CH2:35]3)[C:31](=[O:32])[C:26]2=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[N:28]=[C:27]3[CH2:29][N:30]([CH2:33][C:34]4([CH3:38])[CH2:35][O:36][CH2:37]4)[C:31](=[O:32])[C:26]3=[CH:25][CH:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

参加物

3

反応物 2

HCID 582166602-chloro-6-[(3-methyloxetan-3-yl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-oneHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

生成物 1

HCID 445546325-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(3-methyloxetan-3-yl)methyl]-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl}amino)thiophene-3-carboxamide

実験手順

The title compound was prepared according to the general procedure in Example 1 Step 5 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (130 mg, 0.42 mmol) and 2-chloro-6-[(3-methyloxetan-3-yl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (100 mg, 0.40 mmol) as the starting materials.

出典と根拠

ORDレコード
ord-8c6f8e8d0acb4627bfcf924e10c1b266
出典データセット
uspto-grants-2013_01
特許番号
US08344144B2

関連ノート

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