Hydrochloric Acid → 5-Amino-2-ethylphenol hydrochloride

HRID 1800467ノート

反応式

HRID 1800467 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9]C(=O)C)=[CH:5][C:4]=1[OH:13])[CH3:2].[ClH:14]>>[ClH:14].[NH2:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[C:4]([OH:13])[CH:5]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 68418533N-(4-ethyl-3-hydroxyphenyl)acetamide

生成物 1

HCID 684194645-Amino-2-ethylphenol hydrochloride収率 79%

反応条件

温度
100 °C

実験手順

N-(4-Ethyl-3-hydroxyphenyl)acetamide (3.5 g, 19.5 mmol) was suspended in 5N hydrochloric acid, and the suspension was stirred with heating at 100° C. for 2 hr. The reaction mixture was cooled to room temperature, and the yielded crystals were collected by filtration, and air-dried to give the title compound (2.66 g, 79%) as pale-gray crystals.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe yielded crystals were collected by filtration
  3. customair-dried

出典と根拠

ORDレコード
ord-57cc37448c554306b803438d15dab04a
出典データセット
uspto-grants-2013_01
特許番号
US08344135B2

反応ノート

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