Ethyl Acrylate → 3-(7-bromo-2-oxo-2H-quinolin-1-yl)-propionic acid ethyl ester

HRID 1801455ノート

反応式

HRID 1801455 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[C:13]([O:17][CH2:18][CH3:19])(=[O:16])[CH:14]=[CH2:15]>>[CH2:18]([O:17][C:13](=[O:16])[CH2:14][CH2:15][N:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([Br:1])[CH:11]=2)[CH:6]=[CH:7][C:8]1=[O:12])[CH3:19]

参加物

3

反応物 2

HCID 8821Ethyl AcrylateHCID 142210257-Bromoquinolin-2(1H)-one

生成物 1

HCID 686300483-(7-bromo-2-oxo-2H-quinolin-1-yl)-propionic acid ethyl ester収率 94%

実験手順

The compound was obtained according to procedure H starting from 7-bromoquinolin-2(1H)-one (commercial; 561 mg, 2.5 mmol) and ethyl acrylate (0.27 mL, 2.5 mmol, 1 eq.). The crude orange oil (0.76 g; 94% yield) was used as such in the next step.

後処理

  1. customThe compound was obtained

出典と根拠

ORDレコード
ord-7b1c6348d79747fa8a461d16bfc9ffa5
出典データセット
uspto-grants-2013_01
特許番号
US08349826B2

反応ノート

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