1,4-Dioxane hydrochloride → 1-Methyl-3-pyrrolidinaMine 2HCl
反応式
[CH3:1][N:2]1[CH2:6][CH2:5][CH:4]([NH:7]C(OC(C)(C)C)=O)[CH2:3]1.[ClH:15].O1CCOCC1>>[ClH:15].[ClH:15].[CH3:1][N:2]1[CH2:6][CH2:5][CH:4]([NH2:7])[CH2:3]1参加物
3
実験手順
The prepared N-methyl-3-t-butoxycarbonylaminopyrrolidine (1.8 g, 8.9 mmoles) is dissolved in HCl/dioxane (4N, 44 mL, 256 mmoles) and allowed to stir at RT for 45 min. The dioxane is removed by concentration and N-methyl-3-aminopyrrolidine dihydrochloride salt is dried under high vacuum (1.7 g).
後処理
- customThe dioxane is removed by concentration and N-methyl-3-aminopyrrolidine dihydrochloride salt
- customis dried under high vacuum (1.7 g)
出典と根拠
- ORDレコード
- ord-0ef90fe745574f97a4c1c9bd9b028c38
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08349839B2
反応ノート
読み込み中…