Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

HRID 1801633ノート

反応式

HRID 1801633 の反応式
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 210731871-(Benzo[b]thiophen-4-yl)piperazine

生成物 1

HCID 574825411-(1-Benzothiophen-4-yl)piperazine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the residue and precipitated crystals were filtrated and recrystallized from methanol and 1-benzo[b]thiophen-4-yl-piperazine hydrochloride was obtained as colorless needle-like crystals.

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionEthyl acetate was added to the residue
  3. customprecipitated crystals
  4. filtrationwere filtrated
  5. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-185736e4eccc46a389cb081afc6aeb3e
出典データセット
uspto-grants-2013_01
特許番号
US08349840B2

反応ノート

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