tert-Butyl carbamate → [2-(2-Fluoro-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl ester

HRID 1802289ノート

反応式

HRID 1802289 の反応式
Br[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:11]3[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=3)[N:10]=[C:4]2[CH:3]=1.[C:18](=[O:25])([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[NH2:19]>>[C:21]([O:20][C:18](=[O:25])[NH:19][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:11]3[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=3)[N:10]=[C:4]2[CH:3]=1)([CH3:24])([CH3:23])[CH3:22]

参加物

3

反応物 2

HCID 77922tert-Butyl carbamateHCID 677746577-Bromo-2-(2-fluoropyridin-3-YL)-[1,2,4]triazolo[1,5-A]pyridine

生成物 1

HCID 67776667[2-(2-Fluoro-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl ester収率 70.4%

実験手順

The product was prepared in the same manner as described in example 1c using 7-bromo-2-(2-fluoropyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine (1.1 g, 3.75 mmol) and tert-butyl carbamate (528 mg, 4.5 mmol) as starting materials. The reaction affords [2-(2-fluoro-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl ester (870 mg, 70.4%), as light yellow solid. MS: m/z=330.1 (M+H+).

後処理

  1. customThe product was prepared in the same manner

出典と根拠

ORDレコード
ord-f776d38ad18a4dfc9bb1ef4cb928c7cb
出典データセット
uspto-grants-2013_01
特許番号
US08349824B2

反応ノート

読み込み中…