化工社化工社 化学情報印刷レポート · 研究参考用
O-Xylene → Cetirizine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-(2-Chloroethoxy)acetic acid | HCID 10920584 | — |
| 反応物 | 2-(2-Chloroethoxy)acetamide | HCID 11018931 | — |
| 反応物 | 2-(2-Chloroethoxy)acetonitrile | HCID 14835913 | — |
| 反応物 | 2-Chloroethoxy acetate | HCID 18435677 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Cetirizine | HCID 2678 | — |
反応手順
The compound (I) may be further treated with a 2-chloroethoxy acetic acid derivative such as 2-chloroethoxy acetamide or 2-chloroethoxy acetate or 2-chloroethoxy acetonitrile in the presence of a base such as sodium carbonate or potassium carbonate, and a solvent such as toluene or xylene to obtain the corresponding [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid derivative which on hydrolysis, for example, using sodium hydroxide gives levocetirizine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08350031B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-0709d4e8829142cd93bbdf1360d5fbd2 |
| 出典メモ | uspto-grants-2013_01 |