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Ammonia → 1-(3-Methoxy-4-(6-methylpyridazin-4-yl)phenyl)thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 5-(4-Isothiocyanato-2-methoxyphenyl)-3-methylpyridazine | HCID 86649909 | — |
| 生成物 | 1-(3-Methoxy-4-(6-methylpyridazin-4-yl)phenyl)thiourea | HCID 86649910 | 100% |
反応手順
Step L (5): Methanolic ammonia (2.0 M, 20 mL, 40 mmol) was added to a flask charged with 5-(4-isothiocyanato-2-methoxyphenyl)-3-methylpyridazine (650 mg, 2.53 mmol). After 4 h, the reaction mixture was concentrated in vacuo to afford 1-(3-methoxy-4-(6-methylpyridazin-4-yl)phenyl)thiourea (690 mg, 100% yield). LC-MS (M+H)+ 275.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08349880B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-b0c012bd691049399497d45dcccf01d8 |
| 出典メモ | uspto-grants-2013_01 |