Ammonium Hydroxide → 2,3-Difluoro-5-nitrophenol

HRID 1803151ノート

反応式

HRID 1803151 の反応式
[OH-].[NH4+].C(=O)(OCC)[O:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([F:14])[C:6]=1[F:15]>CCOC(C)=O>[F:15][C:6]1[C:7]([F:14])=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=1[OH:4]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 66859069HCID 66859069、化合物

生成物 1

HCID 221546562,3-Difluoro-5-nitrophenol収率 85%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Step M (3): Aqueous ammonium hydroxide (5 mL) was added to a solution of 2,3-difluoro-5-nitrophenyl ethyl carbonate (250 mg, 1.0 mol) in EtOAc (4 mL). The reaction mixture was quenched with 1 N HCl. The mixture was diluted with water and extracted with EtOAc. The organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to afford 2,3-difluoro-5-nitrophenol (150 mg, 85% yield).

後処理

  1. customThe reaction mixture was quenched with 1 N HCl
  2. additionThe mixture was diluted with water
  3. extractionextracted with EtOAc
  4. washThe organic layer was washed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-960946d47f3c4bf8978c4a0ab66f48b5
出典データセット
uspto-grants-2013_01
特許番号
US08349880B2

反応ノート

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