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1-Chloro-4-iodobutane → 6-Chloro-2-(4-isopropoxyphenyl)hexanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-4-iodobutane | HCID 82527 | — |
| 反応物 | Benzeneacetic acid, 4-(1-methylethoxy)- | HCID 799528 | — |
| 反応物 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 生成物 | 6-Chloro-2-(4-isopropoxyphenyl)hexanoic acid | HCID 58110093 | 37.6% |
反応手順
Step AV (1): 2-(4-Isopropoxyphenyl)acetic acid (7.7 g, 39.6 mmol, reference G. Solladie et al. Tetrahedron (2003), 59, 3315) was deprotonated with NaHMDS (2.0 M in THF, 39.5 mL, 79 mmol) and reacted with 1-chloro-4-iodobutane (10.8 g, 49.6 mmol) using a procedure analogous to Step AC (1) to afford 6-chloro-2-(4-isopropoxyphenyl)hexanoic acid (4.24 g, 37% yield) as a clear viscous oil. LC-MS (M−H)− 193.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08349880B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-c1e30653e83043e8b52e904d30e0a7fa |
| 出典メモ | uspto-grants-2013_01 |