Hydrochloric Acid → (3-Piperazin-1-yl-phenyl)-(2-pyrrolidin-1-yl-ethyl)-amine

HRID 1803602ノート

反応式

HRID 1803602 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.CC(O)C>[N:11]1([C:14]2[CH:15]=[C:16]([NH:20][CH2:21][CH2:22][N:23]3[CH2:24][CH2:25][CH2:26][CH2:27]3)[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 674159094-[3-(2-Pyrrolidin-1-yl-ethylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 67416460(3-Piperazin-1-yl-phenyl)-(2-pyrrolidin-1-yl-ethyl)-amine収率 137.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3776Isopropanol溶媒

実験手順

To a solution of 4-[3-(2-pyrrolidin-1-yl-ethylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (338 mg, 0.90 mmol) in MeOH (10 mL) was added a solution of HCl in IPA (5M, 1.8 mL). The mixture was stirred for 18 h then concentrated to provide the title compound (339 mg, 99%). m/z (M+1) 275.49 (free base).

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-28ca1b2de41b45d6941c320e28d6dbc0
出典データセット
uspto-grants-2013_01
特許番号
US08349836B2

反応ノート

読み込み中…