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Trimethylsilyl iodide → (+/-)-cis-1-(Acetyloxy)-6methoxy-3,3,14-trimethyl-7-oxo-2,3,7,14-tetrahydro-1h-benzo[b]chromeno[6,5-g][1,8]naphthyridin-2-yl aminoacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethylsilyl iodide | HCID 85247 | — |
| 反応物 | (+/-)-cis-1-(Acetyloxy)-6-methoxy-3,3,14-trimethyl-7-oxo-2,3,7,14-tetrahydro-1h-benzo[b]chromeno[6,5-g][1,8]naphthyridin-2-yl [(tert-butoxycarbonyl)amino]acetate | HCID 91322932 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | (+/-)-cis-1-(Acetyloxy)-6methoxy-3,3,14-trimethyl-7-oxo-2,3,7,14-tetrahydro-1h-benzo[b]chromeno[6,5-g][1,8]naphthyridin-2-yl aminoacetate | HCID 68585121 | — |
反応手順
Add 0.14 μl of iodotrimethylsilane to a solution, at ambient temperature, of 0.1 mmol of the compound of Example 10 in 1 ml of chloroform. The reaction mixture is stirred for 5 min. at ambient temperature and then evaporated to dryness under reduced pressure. Chromatography on silica gel (dichloromethane/methanol:85/15) allows the expected product to be isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741325B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f38be1e437c248a88931ebf242c1bcb4 |
| 出典メモ | uspto-grants-2010_06 |