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Chloroform → (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 6-Bromonicotinic acid | HCID 238932 | — |
| 反応物 | 4-(4-Methylphenoxy)piperidine | HCID 3837497 | — |
| 反応物 | 4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate | HCID 23149411 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone | HCID 58484591 | 99.9% |
反応手順
To a mixture of 4-(p-tolyloxy)piperidine (765 mg), 6-bromonicotinic acid (808 mg) and 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMT-MM) (1.7 g) were added chloroform (5 mL) and methanol (5 mL), and the mixture was stirred at room temperature overnight. After evaporation of the solvent, the residue was purified by column chromatography (chloroform:methanol) to give the title compound (1.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08354401B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-31d277f31d42413fbaa18166042e1a7d |
| 出典メモ | uspto-grants-2013_01 |