Ethyl 4-iodobenzoate → (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1803973

反応式

HRID 1803973 の反応式
I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[N:15]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1

参加物

3

反応物 2

HCID 142891Ethyl 4-iodobenzoateHCID 2734858(R)-4-Methyloxazolidin-2-one

生成物 1

HCID 58484719(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

実験手順

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (1.4 mL) and (R)-4-methyloxazolidin-2-one (860 mg) described in Preparation Example 25, the title compound (0.9 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 18
  3. customdescribed in Preparation Example 25

出典と根拠

ORDレコード
ord-e84e8c1253ee489a82819b91954e3aab
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

関連ノート

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