(R)-4-Methyloxazolidin-2-one → (R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1803979

反応式

HRID 1803979 の反応式
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].[CH3:14][C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[NH:16]1>>[CH3:13][O:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:16]1[C@H:15]([CH3:14])[CH2:19][O:18][C:17]1=[O:20])[C:6]([OH:8])=[O:7]

参加物

3

反応物 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 14570117Methyl 4-bromo-3-methoxybenzoate

生成物 1

HCID 58484801(R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid収率 97.5%

実験手順

By reaction and treatment in the same manner as in Preparation Example 45 and using methyl 4-bromo-3-methoxybenzoate (1 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 45
  3. customdescribed in Preparation Example 25

出典と根拠

ORDレコード
ord-dfc5d763c3244908b695e300cb61484a
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

関連ノート

読み込み中…