6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804020ノート

反応式

HRID 1804020 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:8])=[CH:9][CH:10]=1

参加物

3

反応物 2

HCID 2389326-Bromonicotinic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

生成物 1

HCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone収率 99.9%

実験手順

By reaction and treatment in the same manner as in Preparation Example 67 and using 6-bromonicotinic acid (808 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (765 mg) described in Preparation Example 47, the title compound (1.5 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 67
  3. customdescribed in Preparation Example 47

出典と根拠

ORDレコード
ord-dd1fcf73389147b48bd2fc583ef2e1c4
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…