Ethyl 4-iodobenzoate → (R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

反応式

I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[NH:17]1)[CH2:14][CH3:15]>>[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1)[CH2:14][CH3:15]

参加物

反応物 2

HCID 142891Ethyl 4-iodobenzoate

HCID 2734859(4R)-4-Propyl-2-oxazolidinone

生成物 1

HCID 58484846(R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

実験手順

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (3.2 mL) and (R)-4-propyloxazolidin-2-one (2.5 g) described in Preparation Example 29, the title compound (5.7 g) was obtained.

後処理

customBy reaction and treatment in the same manner
customas in Preparation Example 18
customdescribed in Preparation Example 29

出典と根拠

ORDレコード: ord-846ed9f5f6aa4559b318bb374851e081
出典データセット: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08354401B2

反応ノート

読み込み中…

参加物