6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone
反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.Cl.[CH:12]1([C:15]2[C:16]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[N:17][CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=2)[CH2:14][CH2:13]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:28]2[CH2:29][CH2:30][N:25]([C:16]3[C:15]([CH:12]4[CH2:14][CH2:13]4)=[CH:20][C:19]([C:21]([F:24])([F:22])[F:23])=[CH:18][N:17]=3)[CH2:26][CH2:27]2)=[O:8])=[CH:9][CH:10]=1参加物
3
実験手順
By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (667 mg) and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride (1.2 g) described in Preparation Example 76, the title compound (1.6 g) was obtained.
後処理
- customBy reaction and treatment in the same manner
- customas in Preparation Example 27