4-Bromo-2-fluorobenzoic acid → (4-Bromo-2-fluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804128

反応式

HRID 1804128 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH3:12][C:13]1[CH:14]=[CH:15][C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:16]3[CH:15]=[CH:14][C:13]([CH3:12])=[CH:18][N:17]=3)[CH2:20][CH2:21]2)=[O:8])=[C:4]([F:11])[CH:3]=1

参加物

3

反応物 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 114807791-(5-Methyl-2-pyridinyl)piperazine

生成物 1

HCID 58484600(4-Bromo-2-fluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone収率 88.9%

実験手順

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-fluorobenzoic acid (1.45 g) and 1-(5-methylpyridin-2-yl)piperazine (1.06 g) described in Preparation Example 183, the title compound (2.01 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 183

出典と根拠

ORDレコード
ord-473bee038c0a495ea5ae79571b1e382e
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

関連ノート

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