4-Bromo-2,6-difluorobenzoic acid → (4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804132ノート

反応式

HRID 1804132 の反応式
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:5]([C:6]([OH:8])=O)=[C:4]([F:12])[CH:3]=1.[CH:13]1([C:16]2[CH:17]=[CH:18][C:19]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[N:20][CH:21]=2)[CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:3]=[C:4]([F:12])[C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:19]3[CH:18]=[CH:17][C:16]([CH:13]4[CH2:15][CH2:14]4)=[CH:21][N:20]=3)[CH2:23][CH2:24]2)=[O:8])=[C:9]([F:11])[CH:10]=1

参加物

3

反応物 2

HCID 27732984-Bromo-2,6-difluorobenzoic acidHCID 584848401-(5-Cyclopropylpyridin-2-yl)piperazine

生成物 1

HCID 58484548(4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone収率 88.9%

実験手順

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2,6-difluorobenzoic acid (1.20 g) and 1-(5-cyclopropylpyridin-2-yl)piperazine (1.15 g) described in Preparation Example 187, the title compound (1.90 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 187

出典と根拠

ORDレコード
ord-527e661c79384a75a53ea16f4a69c358
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

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