2-Oxazolidinone → 3-{4-[4-(2-Cyclopropyl-4-methylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804166ノート

反応式

HRID 1804166 の反応式
[CH:1]1([C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=2[N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[CH:24]=[CH:23][C:22](I)=[CH:21][CH:20]=3)=[O:18])[CH2:13][CH2:12]2)[CH2:3][CH2:2]1.[O:26]1[CH2:30][CH2:29][NH:28][C:27]1=[O:31]>>[CH:1]1([C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=2[N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[CH:24]=[CH:23][C:22]([N:28]4[CH2:29][CH2:30][O:26][C:27]4=[O:31])=[CH:21][CH:20]=3)=[O:18])[CH2:13][CH2:12]2)[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 739492-OxazolidinoneHCID 58484789[4-(2-Cyclopropyl-4-methylphenyl)piperazin-1-yl](4-iodophenyl)methanone

生成物 1

HCID 461901753-{4-[4-(2-Cyclopropyl-4-methylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one収率 27.1%

実験手順

By reaction and treatment in the same manner as in Example 1 and using [4-(2-cyclopropyl-4-methylphenyl)piperazin-1-yl](4-iodophenyl)methanone (280 mg) described in Preparation Example 17 and oxazolidin-2-one (313 mg), the title compound (69 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 1

出典と根拠

ORDレコード
ord-ff6acbb897ce4558ab5d1d19fcf66a52
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…