4-(4-Methylphenoxy)piperidine → (R)-4-methyl-3-[4-(4-p-tolyloxypiperidine-1-carbonyl)phenyl]oxazolidin-2-one

HRID 1804182ノート

反応式

HRID 1804182 の反応式
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1.[CH3:15][C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=1>>[CH3:15][C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:22]1[CH:30]=[CH:29][C:25]([C:26]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][C:4]3[CH:3]=[CH:2][C:1]([CH3:14])=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)=[O:27])=[CH:24][CH:23]=1

参加物

3

反応物 2

HCID 38374974-(4-Methylphenoxy)piperidineHCID 58484719(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

生成物 1

HCID 67381285(R)-4-methyl-3-[4-(4-p-tolyloxypiperidine-1-carbonyl)phenyl]oxazolidin-2-one収率 77.6%

実験手順

By reaction and treatment in the same manner as in Example 52 and using 4-(p-tolyloxy)piperidine (1 g) and (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (1.2 g) described in Preparation Example 37, the title compound (1.6 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 52
  2. customdescribed in Preparation Example 37

出典と根拠

ORDレコード
ord-878a4ab351534d078c1b314cc1ef2612
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…