(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-4-isopropyl-3-{4-[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804190ノート

反応式

HRID 1804190 の反応式
[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)([CH3:3])[CH3:2].[CH3:19][C:20]1[C:21]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[N:22][CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1>>[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:33]2[CH2:34][CH2:35][N:30]([C:21]3[C:20]([CH3:19])=[CH:25][C:24]([C:26]([F:29])([F:27])[F:28])=[CH:23][N:22]=3)[CH2:31][CH2:32]2)=[O:16])=[CH:17][CH:18]=1)([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 58484694(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acidHCID 584847291-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine

生成物 1

HCID 67380990(R)-4-isopropyl-3-{4-[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one収率 30.7%

実験手順

By reaction and treatment in the same manner as in Example 29 and using (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (499 mg) described in Preparation Example 18 and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (490 mg) described in Preparation Example 51, the title compound (292 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 29
  2. customdescribed in Preparation Example 51

出典と根拠

ORDレコード
ord-777b159fbf0b40bb9066bac907350dc0
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…