(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one

HRID 1804192ノート

反応式

HRID 1804192 の反応式
Cl.[CH:2]1([C:5]2[CH:6]=[C:7]([CH3:17])[C:8]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[N:9][CH:10]=2)[CH2:4][CH2:3]1.[CH:18]([C@@H:21]1[CH2:25][O:24][C:23](=[O:26])[N:22]1[C:27]1[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=1)([CH3:20])[CH3:19]>>[CH:2]1([C:5]2[CH:6]=[C:7]([CH3:17])[C:8]([N:11]3[CH2:12][CH2:13][N:14]([C:31]([C:30]4[CH:29]=[CH:28][C:27]([N:22]5[C@H:21]([CH:18]([CH3:19])[CH3:20])[CH2:25][O:24][C:23]5=[O:26])=[CH:35][CH:34]=4)=[O:32])[CH2:15][CH2:16]3)=[N:9][CH:10]=2)[CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 58484694(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acidHCID 673810911-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride

生成物 1

HCID 67380778(R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one収率 42.5%

実験手順

By reaction and treatment in the same manner as in Example 29 and using 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (381 mg) described in Preparation Example 49 and (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (374 mg) described in Preparation Example 18, the title compound (286 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 29
  2. customdescribed in Preparation Example 18

出典と根拠

ORDレコード
ord-55c3636361f740d28556b1608087f7ba
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…