(R)-4-Methyloxazolidin-2-one → (R)-3-{3-chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one hydrochloride

HRID 1804212ノート

反応式

HRID 1804212 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([Cl:24])[CH:3]=1.[CH3:25][C@@H:26]1[CH2:30][O:29][C:28](=[O:31])[NH:27]1>>[ClH:24].[Cl:24][C:4]1[CH:3]=[C:2]([N:27]2[C@H:26]([CH3:25])[CH2:30][O:29][C:28]2=[O:31])[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=2)[CH2:12][CH2:11]1)=[O:9]

参加物

3

反応物 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484833(4-Bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

生成物 1

HCID 67446415(R)-3-{3-chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one hydrochloride収率 30.9%

実験手順

By reaction and treatment in the same manner as in Example 79 and using (4-bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (1.7 g) described in Preparation Example 69 and (R)-4-methyloxazolidin-2-one (510 mg) described in Preparation Example 25, the title compound (299 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 79
  2. customdescribed in Preparation Example 25

出典と根拠

ORDレコード
ord-9be0a5ad6570454d9642aa47d4e0422b
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…