(S)-5-methyloxazolidin-2-one → (S)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methyloxazolidin-2-one

HRID 1804246ノート

反応式

HRID 1804246 の反応式
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:28][C@@H:29]1[O:33][C:32](=[O:34])[NH:31][CH2:30]1>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:31]5[CH2:30][C@H:29]([CH3:28])[O:33][C:32]5=[O:34])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 21794663(S)-5-methyloxazolidin-2-oneHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

生成物 1

HCID 67380974(S)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methyloxazolidin-2-one収率 76.9%

実験手順

By reaction and treatment in the same manner as in Example 149 and using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 95 and (S)-5-methyloxazolidin-2-one (121 mg) described in Preparation Example 42, the title compound (343 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 149
  2. customdescribed in Preparation Example 42

出典と根拠

ORDレコード
ord-4199f1484e5f4fb9bb02b34c60d3ffbc
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

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